Our research works focus on development of synthetic methodology and synthesis of biologically active compounds based on green chemistry concept.

1. C-O bond cleavage of alcohols and ethers

1.1 Deoxygenation of epoxides to alkenes

This methodology could be an alternative approach for alkene isomerization and also one of the method for utilization of biomass as renewable chemicals.

1.2 Suzuki-Miyaura cross-coupling of benzylic alcohols

C(sp³)-C(sp²) bond formation via Suzuki-Miyaura cross-coupling of non-derivatized benzylic alcohols is a greener alternative method to use benzylic halides is ongoing to develop.

References : Org. Lett. 2019, 21, 4782-4787, Synthesis 2020, 52, 645-659.

2. Asymmetric synthesis of biologically active molecules

2.1 Synthesis of Chrysosporazine A-C

• Akkarasamiyo, S.; Rujirawat, S.; Ploypradith, P.; Samec, J.S.M. Transition-Metals Catalyzed Suzuki-Miyaura Type Cross Coupling Reaction of p-Activated Alcohols Synthesis 2020, 52(5), 645-659
• Akkarasamiyo, S.; Samec, J.S.M. Intermolecular Stereospecific Substitution of Underivatized Enantioenriched Secondary Alcohols by Organocatalysis (Highlight) Angew. Chem. Int. Ed. 2019, 58(50), 17908-17910.
• Watile, R. A.; Bunrit, A.; Margalef, J.; Akkarasamiyo, S.; Ayub, R.; Lagerspets, E.; Biswas, S.; Repo, T.; Samec, J.S.M. Intramolecular substitutions of secondary and tertiary alcohols with chirality transfer by an iron (III) catalyst Nature Comm. 2019, 10:3826.
• Akkarasamiyo, S.; Margalef, J.; Samec, J. S. M. Nickel-Catalyzed Suzuki-Miyaura Cross-Coupling Reaction of Naphthyl and Quinolyl Alcohols with Boronic Acids Org. Lett. 2019, 21, 4782-4787.
• Rukkijakan, T.; Akkarasamiyo, S.; Sawadjoon, S.; Samec, J. S. M. Pd-catalyzed substitution of the OH group of non-derivatized allylic alcohols by phenols J. Org. Chem. 2018, 83(7), 4099-4104.
• Akkarasamiyo, S.; Sawadjoon, S.; Orthaber, A.; Samec, J. S. M. Tsuji-Trost Reaction of Non-Derivatized Allylic Alcohols. Chem. Eur. J.  2018, 24(14), 3488–3498.
• Gupta, A. K.; Akkarasamiyo, S.; Orthaber, A. Rich Coordination Chemistry of π‑Acceptor Dibenzoarsole Ligands. Inorg. Chem. 2017, 56, 4504−4511.